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N-Caffeoyltryptophan

Catalog No. TN7093   CAS 109163-69-1
Synonyms: trans-Caffeoyl-L-tryptophan

N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).

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N-Caffeoyltryptophan Chemical Structure
N-Caffeoyltryptophan, CAS 109163-69-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 336.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
1 mL * 10 mM (in DMSO) In stock $ 357.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
Targets&IC50 SIRT1:34μM, Sirt2:8.7 μM
In vitro In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1].
Synonyms trans-Caffeoyl-L-tryptophan
Molecular Weight 366.37
Formula C20H18N2O5
CAS No. 109163-69-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (122.83 mM)

TargetMolReferences and Literature

1. Park JB. Finding Potent Sirt Inhibitor in Coffee: Isolation, Confirmation and Synthesis of Javamide-II (N-Caffeoyltryptophan) as Sirt1/2 Inhibitor. PLoS One. 2016 Mar 17;11(3):e0150392.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max RO5 Drug-like Natural Product Library Epigenetics Compound Library Human Metabolite Library Natural Product Library for HTS Human Endogenous Metabolite Compound Library Plus Inhibitor Library Natural Product Library

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Keywords

N-Caffeoyltryptophan 109163-69-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin trans-Caffeoyl-L-tryptophan N Caffeoyltryptophan NCaffeoyltryptophan inhibitor inhibit

 

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