Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 148.00 | |
5 mg | In stock | $ 336.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 357.00 |
Description | N-Caffeoyltryptophan (trans-Caffeoyl-L-tryptophan), a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM). |
Targets&IC50 | SIRT1:34μM, Sirt2:8.7 μM |
In vitro | In cellular levels,N-Caffeoyltryptophan was able to increase the acetylation of total lysine, cortactin and histone H3 in neuronal NG108-15 cells. In the same cells, the amide also increased the acetylation of lysine (K382) in p53, but not (K305)[1]. |
Synonyms | trans-Caffeoyl-L-tryptophan |
Molecular Weight | 366.37 |
Formula | C20H18N2O5 |
CAS No. | 109163-69-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (122.83 mM)
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N-Caffeoyltryptophan 109163-69-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin trans-Caffeoyl-L-tryptophan N Caffeoyltryptophan NCaffeoyltryptophan inhibitor inhibit