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N-Glycolylneuraminic acid

Catalog No. T19456 CAS 1113-83-3

Synonyms: NeuGc, GcNeu

N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

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N-Glycolylneuraminic acid Chemical Structure

N-Glycolylneuraminic acid, CAS 1113-83-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 44.00
2 mg	In stock	$ 63.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 278.00
50 mg	In stock	$ 428.00
100 mg	In stock	$ 623.00
1 mL * 10 mM (in DMSO)	In stock	$ 116.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

N-Glycolylneuraminic acid (GcNeu) is a nonhuman sialic acid molecule synthesized in pigs. N-Glycolylneuraminic acid is a receptor of human and animal IAVs.

In vitro

Expression of N-Glycolylneuraminic acid on human cells clearly suppressed infectivity of IAVs that possess N-Glycolylneuraminic acid binding ability. Furthermore, there was no difference in infectivity of a transfectant virus that included the wild-type HA gene from A/Memphis/1/1971 (H3N2), which shows no N-Glycolylneuraminic acid binding, between parent MCF7 cells and cells stably expressing the monkey CMAH gene (CMAH-MCF7 cells). On the other hand, cell entry of the transfectant virus that included the N-Glycolylneuraminic acid-binding HA gene with a single mutation to Tyr at position Thr155 was arrested at the stage of internalization from the plasma membrane of the CMAH-MCF7 cells[1].

Synonyms	NeuGc, GcNeu
Molecular Weight	325.27
Formula	C11H19NO10
CAS No.	1113-83-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 76 mg/mL (233.65 mM)

References and Literature

1. Takahashi T, et al. N-glycolylneuraminic acid on human epithelial cells prevents entry of influenza A viruses that possess N-glycolylneuraminic acid binding ability. J Virol. 2014 Aug;88(15):8445-56.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Viral Compound Library Human Endogenous Metabolite Compound Library Plus Bioactive Compounds Library Max Bioactive Compound Library Covalent Inhibitor Library Human Metabolite Library

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Keywords

N-Glycolylneuraminic acid 1113-83-3 Metabolism Microbiology/Virology Influenza Virus Endogenous Metabolite NeuGc Inhibitor NGlycolylneuraminic acid inhibit N Glycolylneuraminic acid GcNeu inhibitor

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