Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-Oleoyl glycine, a lipoamino acid, was able to promote 3T3-L1 adipogenesis through the activation of CB1 receptor and the enhancement of insulin-mediated Akt signaling pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 64.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 153.00 | |
100 mg | In stock | $ 229.00 | |
200 mg | In stock | $ 342.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | N-Oleoyl glycine, a lipoamino acid, was able to promote 3T3-L1 adipogenesis through the activation of CB1 receptor and the enhancement of insulin-mediated Akt signaling pathway. |
In vitro | N-Oleoyl glycine stimulated lipid accumulation and significantly increased adipogenic genes (PPARγ and aP2), in a dose- and time-dependent manner.?Additionally, N-Oleoyl glycine markedly increased the mRNA expression of CB1 receptor and the inhibition of CB1R by its antagonist SR141716 abolished the promotive effects of N-Oleoyl glycine on lipid accumulation and the protein expression of PPARγ and aP2.?Furthermore, N-Oleoyl glycine increased the ratio of p-Akt/Akt and p-FoxO1/FoxO1, which could be reversed by SR141716.?Moreover, N-Oleoyl glycine-induced enhancement of adipogenesis, activation of insulin-mediated Akt signaling pathway and inactivation of FoxO1 were effectively blocked by Wortmannin, a specific PI3K/Akt inhibitor, indicating the essential role of Akt signaling pathway in the process of N-Oleoyl glycine-stimulated 3T3-L1 adipogenesis[1]. |
Molecular Weight | 339.51 |
Formula | C20H37NO3 |
CAS No. | 2601-90-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (235.63 mM)
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N-Oleoyl glycine 2601-90-3 Cytoskeletal Signaling DNA Damage/DNA Repair GPCR/G Protein Metabolism PI3K/Akt/mTOR signaling Endogenous Metabolite Akt PPAR Cannabinoid Receptor Inhibitor NOleoyl glycine Protein kinase B N Oleoyl glycine PKB inhibit inhibitor