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NB-598 hydrochloride

Catalog No. T12199L CAS 136719-25-0

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

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NB-598 hydrochloride, CAS 136719-25-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Storage & Solubility Information

Description

NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

In vitro

NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia.?NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG).?When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG.?Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly.?After incubating Caco-2 cells with 10 microM NB-598, a slight reduction in cellular ACAT activity was also observed.?These results suggest that suppression of the secretion of particles containing apo B and reduction of cellular ACAT activity in the intestinal epithelia are part of the mechanism of the cholesterol-lowering effect of NB-598.

Molecular Weight	486.13
Formula	C27H32ClNOS2
CAS No.	136719-25-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Xia F, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45. 2. Horie M, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305. 3. Horie M, et al. An inhibitor of squalene epoxidase, NB-598, suppresses the secretion of cholesterol and triacylglycerol and simultaneously reduces apolipoprotein B in HepG2 cells. Biochim Biophys Acta. 1993 May 20;1168(1):45-51.

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Keywords

NB-598 hydrochloride 136719-25-0 Microbiology/Virology Antifungal NB-598 Hydrochloride NB598 hydrochloride NB 598 Hydrochloride NB598 Hydrochloride NB 598 hydrochloride inhibitor inhibit

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