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NF-κB-IN-1

Catalog No. T9105   CAS 1227098-15-8
Synonyms: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-

NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
NF-κB-IN-1 Chemical Structure
NF-κB-IN-1, CAS 1227098-15-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 187.00
5 mg In stock $ 397.00
10 mg In stock $ 589.00
25 mg In stock $ 945.00
50 mg In stock $ 1,280.00
100 mg In stock $ 1,730.00
500 mg In stock $ 3,460.00
1 mL * 10 mM (in DMSO) In stock $ 463.00
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Purity: 99.29%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.
In vitro NF-κB-IN-1 (0.5-25 μM; pretreated for 30 min or 4 h) potently blocks the IκB phosphorylation and degradation in A549 cells.It(0.001-100 μM; 72 h) inhibits the growth of A549, H1944, H460 and H157 cells, with GI50s of 0.72, 0.07, 0.13, and 0.16 μM, respectively.NF-κB-IN-1 (0.1-0.4 μM; 9 d) inhibits lung cancer clonogenic activity. NF-κB-IN-1 (0.1-100 μM; pretreated for 30 min) dose-dependently inhibits the TNFα-induced nuclear translocation of NF-κB in A549 cells, with an IC50s of 1.0 μM[1].
Synonyms 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
Molecular Weight 530.57
Formula C31H30O8
CAS No. 1227098-15-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (94.24 mM), sonification is recommended.

TargetMolReferences and Literature

1. Qiu X, et, al. Synthesis and identification of new 4-arylidene curcumin analogues as potential anticancer agents targeting nuclear factor-κB signaling pathway. J Med Chem. 2010 Dec 9;53(23):8260-73.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Transcription Factor-Targeted Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Bioactive Compound Library NO PAINS Compound Library NF-κB Signaling Compound Library Anti-Prostate Cancer Compound Library Antidepressant Compound Library

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Keywords

NF-κB-IN-1 1227098-15-8 NF-Κb NF-κB IκB/IKK pathway 4-arylidene Inhibitor inhibit NF-kB-IN-1 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- IKK crucumin cancer A549 NFκBIN1 I kappa B kinase signaling NF κB IN 1 NF-kappaB-IN-1 IκB kinase inhibitor

 

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