Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 66.00 | |
5 mg | In stock | $ 143.00 | |
10 mg | In stock | $ 243.00 | |
25 mg | In stock | $ 449.00 | |
50 mg | In stock | $ 665.00 | |
100 mg | In stock | $ 947.00 | |
500 mg | In stock | $ 1,890.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 157.00 |
Description | NFAT Transcription Factor Regulator-1 is an synthesis inhibitor of IL-2 (IC50 of 182 nM). |
Targets&IC50 | IL-2 synthesis:182 nM |
In vitro | NFAT Transcription Factor Regulator-1 inhibits IL-2 synthesis(IC50 of 182 nM). NFAT Transcription Factor Regulator-1 inhibits human and rat PBMC proliferation with IC50s of 82 and 146 nM, respectively. NFAT Transcription Factor Regulator-1 is able to inhibit IL-4 and IL-5 production in human T-cell lines with similar potency to its effects on IL-2 release. |
In vivo | NFAT Transcription Factor Regulator-1 demonstrates an inhibitory potency on T-cell IL-2 production that is approximately 10 times greater than cyclosporine, requiring doses of 3.0 mg/kg and 30 mg/kg, respectively, for comparable effects. In vivo studies in monkeys further reveal the potential of NFAT Transcription Factor Regulator-1 to block T-cell cytokine production effectively, suggesting its viability as a transplantation aid comparable to cyclosporine[1]. |
Molecular Weight | 416.28 |
Formula | C17H10F6N4O2 |
CAS No. | 245747-71-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (216.2 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NFAT Transcription Factor Regulator-1 245747-71-1 Immunology/Inflammation IL Receptor NFAT Transcription Factor Regulator 1 NFAT Transcription Factor Regulator1 inhibitor inhibit