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NP213

Catalog No. TP2149L CAS 942577-31-3

NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.

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NP213, CAS 942577-31-3

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Description	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
In vivo	NP213 demonstrates both tolerability and efficacy, with a half-life of approximately 4.5 hours in murine models of acute disseminated candidiasis. At a dosage of 25 mg/kg, NP213 is well-tolerated in mice [3].

Molecular Weight	1093.3
Formula	C42H84N28O7
CAS No.	942577-31-3

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mercer DK,et al. Improved Methods for Assessing Therapeutic Potential of Antifungal Agents against Dermatophytes and Their Application in the Development of NP213, a Novel Onychomycosis Therapy Candidate.Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02117-18 2. Neelabh, et al. Sequential and Structural Aspects of Antifungal Peptides from Animals, Bacteria and Fungi Based on Bioinformatics Tools.Probiotics Antimicrob Proteins. 2016 Jun;8(2):85-101. 3. Novamycin®/NP339 Technology Summary

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Keywords

NP213 942577-31-3 Chromatin/Epigenetic Epigenetic Reader Domain NP 213 NP-213 inhibitor inhibit

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