Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC-65809 (Raphin1) is a selective inhibitor of R15B.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
2 mg | In stock | $ 198.00 | |
5 mg | In stock | $ 298.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 267.00 |
Description | NSC-65809 (Raphin1) is a selective inhibitor of R15B. |
In vitro | In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment |
In vivo | Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease. |
Synonyms | 3-[(2,3-dichlorophenyl)methylene]carbazamidine, Raphin1 |
Molecular Weight | 231.08 |
Formula | C8H8Cl2N4 |
CAS No. | 94023-67-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/mL (151.46 mM)
You can also refer to dose conversion for different animals. More
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NSC 65809 94023-67-3 Metabolism Phosphatase NSC-65809 3-[(2,3-dichlorophenyl)methylene]carbazamidine NSC65809 Raphin1 inhibitor inhibit