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NSC23005 Sodium

Catalog No. T3589 CAS 1796596-46-7

NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.

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NSC23005 Sodium, CAS 1796596-46-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 39.00
2 mg	In stock	$ 54.00
5 mg	In stock	$ 85.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 257.00
50 mg	In stock	$ 459.00
100 mg	In stock	$ 658.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.71%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.
Targets&IC50	p18INK4C:5.21 nM (ED50)
In vitro	NSC23005 sodium is a novel class of INK4C (p18INK4C or p18) small molecule inhibitor (p18SMIs), which is initially found by in silico 3D screening. NSC23005 sodium shows the most potent bioactivity in hematopoietic stem cells (HSCs) expansion (ED50=5.21 nM). Notably, NSC23005 sodium does not show significant cytotoxicity toward 32D cells or HSCs, nor does it augment leukemia cell proliferation. NSC23005 sodium (ED50=5.21 nM), shows no activity in promoting the proliferation of leukemia cells.
In vivo	NSC23005 sodium selectively promote HSCs division by inhibiting p18, thereby activating CDK4/6. NSC23005 sodium is a novel and effective p18 inhibitor in promoting HSCs expansion in both murine and human models without significant cytotoxicity toward HSCs, nor did it augment leukemia cell proliferation.
Cell Research	NSC23005 sodium is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. c-Kit enriched bone marrow (BM) cells are cultured for 5 days with cytokine combination plus NSC23005 sodium or DMSO. As positive controls, primary uncultured bone marrow cells are treated by ultraviolet radiation (UV) for 10 minutes prior to the staining process for apoptosis analysis. Apoptosis and cell death are measured by AnnexinV and DAPI staining in the Annexin V-FITC Apoptosis Detection Kit. Apoptosis is measured on an FACS analyzer. The data is analyzed using FlowJo software[1].

Molecular Weight	305.32
Formula	C13H16NNaO4S
CAS No.	1796596-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (196.52 mM)

References and Literature

1. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Pancreatic Cancer Compound Library Cell Cycle Compound Library Bioactive Compounds Library Max Kinase Inhibitor Library Anti-Breast Cancer Compound Library Stem Cell Differentiation Compound Library Anti-Cancer Compound Library Bioactive Compound Library NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

NSC23005 Sodium 1796596-46-7 Cell Cycle/Checkpoint CDK NSC23005 NSC 23005 NSC-23005 Sodium inhibit NSC-23005 Inhibitor inhibitor

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