Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 77.00 | |
2 mg | In stock | $ 111.00 | |
5 mg | In stock | $ 198.00 | |
10 mg | In stock | $ 298.00 | |
25 mg | In stock | $ 538.00 | |
50 mg | In stock | $ 777.00 | |
100 mg | In stock | $ 1,090.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 213.00 |
Description | NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival. |
Targets&IC50 | IRS1/2:0.3 to 0.8 μM |
In vitro | NT157 treatment resulted in dose-dependent inhibition of IGF1R activation, suppression of IRS protein expression, inhibition of IGF1-induced AKT activation, but increased ERK activation in NT157-treated cells in vitro[2]. |
In vivo | NT157 suppressed androgen-responsive growth, delayed CRPC progression of LNCaP xenografts, and suppressed PC3 tumor growth alone and in combination with docetaxel[2]. |
Molecular Weight | 412.26 |
Formula | C16H14BrNO5S |
CAS No. | 1384426-12-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 77 mg/ml(186.78 mM)
Ethanol: 25.83mg/ml(186.78 mM)
You can also refer to dose conversion for different animals. More
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NT157 1384426-12-3 JAK/STAT signaling Stem Cells Tyrosine Kinase/Adaptors IGF-1R STAT NT-157 NT 157 inhibitor inhibit