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NVP-CGM097 sulfate

Catalog No. T12273 CAS 1313367-56-4

Synonyms: CGM097 sulfate

NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM).

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NVP-CGM097 sulfate, CAS 1313367-56-4

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,070.00
50 mg	10-14 weeks	$ 1,390.00
100 mg	10-14 weeks	$ 1,990.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM).
Targets&IC50	MDM2 (human):1.7±0.1 nM
In vitro	NVP-CGM097 is able to significantly redistribute wild-type p53 into the cell nucleus with an IC50 of 0.224 μM, demonstrating its ability to inhibit the p53:MDM2 interaction in living cells.?NVP-CGM097 significantly inhibits the proliferation of cells expressing wild-type p53, while sparing the p53 null cells with a 35-58-fold difference.?NVP-CGM097 inhibtis HCT116 (p53WT/WT) with IC50 of 454±136 nM[1].

Synonyms	CGM097 sulfate
Molecular Weight	757.34
Formula	C38H49ClN4O8S
CAS No.	1313367-56-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 140 mg/mL (184.86 mM)

References and Literature

1. Holzer P, et al. Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NVP-CGM097 sulfate 1313367-56-4 Others NVP-CGM097 Sulfate CGM097 sulfate CGM-097 Sulfate NVP-CGM 097 Sulfate NVPCGM097 sulfate NVP-CGM-097 sulfate CGM097 Sulfate NVP-CGM-097 Sulfate NVP CGM097 sulfate CGM 097 Sulfate inhibitor inhibit

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