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Naringin dihydrochalcone

Catalog No. T2761 CAS 18916-17-1

Synonyms: Naringin DC

Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.

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Naringin dihydrochalcone Chemical Structure

Naringin dihydrochalcone, CAS 18916-17-1

Pack Size	Availability	Price/USD	Quantity
500 mg	In stock	$ 42.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.16%

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Description	Naringin dihydrochalcone (Naringin DC) is an inhibitor of CYP enzymes, used as an artificial sweetener.
In vitro	Naringin Dihydrochalcone(Naringin DC) is a new-style sweetening agent and an artificial sweetener derived from naringin, a bitter compound found in citrus. [1] It is 500-700 times sweeter than sucrose. Due to its many advantages like high sweet taste, low caloric, innocuity and safety, it can be used in edible, medicine and commodity trade. And because it tastes cleanlily, has long aftertaste and special faint scent and owns fine virtue of shielding bitterness, Naringin DC is in particular used for milky goods, fattiness and grease, freezed foodstuff, machining vegetable, jelly, comfiture, nonalcohol beverage, chewing gum, toothpaste and troche. Besides, it can substitute sugar for decreasing body absorption to sugar. It is really a evangel for fat person and patients who can not eat sugar.
In vivo	Treatment with naringin significantly mitigates renal injury in diabetic rats, while also substantially boosting their body weight. Additionally, naringin administration notably reduces collagen deposition and renal interstitial fibrosis. This treatment is associated with decreased levels of ROS (Reactive Oxygen Species) and MDA (Malondialdehyde), alongside enhanced activities of SOD (Superoxide Dismutase) and GSH-Px (Glutathione Peroxidase)[2]. Oral administration of naringin markedly improves cognitive functions, specifically learning and memory abilities. Furthermore, it substantially strengthens the insulin signaling pathway[3].
Cell Research	HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μl of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μl of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].
Source	Natural Products > Rutaceae > Citrus

Synonyms	Naringin DC
Molecular Weight	582.55
Formula	C27H34O14
CAS No.	18916-17-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (159.6 mM)

DMSO: 93 mg/mL (159.6 mM)

References and Literature

1. Shin W, et al. J Med Chem, 1995, 38(21), 4325-4331. 2. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868. 3. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Inhibitor Library Pyroptosis Compound Library Anti-Tumor Natural Product Library Transcription Factor-Targeted Compound Library NF-κB Signaling Compound Library Anti-Metabolism Disease Compound Library Immunology/Inflammation Compound Library HIF-1 Signaling Pathway Compound Library Chinese Pharmacopoeia Natural Product Library

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Keywords

Naringin dihydrochalcone 18916-17-1 Metabolism NF-Κb P450 NF-κB Naringin DC Inhibitor Nuclear factor-κB Nuclear factor-kappaB inhibit inhibitor

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