Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 228.00 | |
10 mg | In stock | $ 328.00 | |
25 mg | In stock | $ 558.00 | |
50 mg | In stock | $ 788.00 | |
100 mg | In stock | $ 1,120.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 329.00 |
Description | NecroX-5, a derivative of NecroX, exhibits anti-inflammatory and anti-cancer activities. NecroX-5 reduces intracellular calcium concentration. |
In vitro | NecroX-5 (10-40 μM) reduces mitochondrial ROS levels and inhibits AKT and breast cancer cell migration. NecroX-5 (10 μM) blocks Ca2+ influx and decreases intracellular calcium concentration in 4T1 cells[1]. In LPS-stimulated H9C2 cells, NecroX-5 (10 µM), effectively decreases the increased TGF-β1, pSmad2, TNF-α and the expression of Dcn[2]. |
In vivo | In TUBO-P2J tumour-bearing mice, NecroX-5 (2.5 mg/kg) inhibits the metastasis of breast cancer cell[1]. |
Molecular Weight | 645.81 |
Formula | C27H39N3O9S3 |
CAS No. | 1383718-29-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 153.0 mg/mL (236.9 mM ), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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NecroX-5 1383718-29-3 Membrane transporter/Ion channel Metabolism Calcium Channel NecroX 5 NecroX5 inhibitor inhibit