Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 78.00 | |
5 mg | 5 days | $ 166.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 148.00 |
Description | Necrostatin 2 is an effective necroptosis inhibitor. Necrostatin 2 is also a RIPK1 inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. |
In vitro | Necrostatin 2 displays activity in a broad range of necroptosis cellular systems[1]. Necrostatin 2 at 30 μM fully protects L929 cells from TNF-α-induced necroptosis. In addition to TNF-α, the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (zVAD.fmk) has also been found to induce necrosis in L929 cells, which is efficiently inhibited by Necrostatin 2[2]. Evaluation of necroptosis inhibitory activity is performed using a FADD-deficient variant of human Jurkat T cells treated with TNF-α. Utilizing these conditions the cells efficiently undergo necroptosis, which is completely and selectively inhibited by Necrostatin 2 (EC50=50 nM). EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM[3]. |
Molecular Weight | 277.71 |
Formula | C13H12ClN3O2 |
CAS No. | 852391-19-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (360.09 mM)
You can also refer to dose conversion for different animals. More
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Necrostatin 2 852391-19-6 Others inhibitor inhibit