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Neferine

Catalog No. T5S1097   CAS 2292-16-2
Synonyms: (R)-1,2-Dimethoxyaporphine, (-)-Neferine

1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Neferine Chemical Structure
Neferine, CAS 2292-16-2
Pack Size Availability Price/USD Quantity
5 mg In stock $ 43.00
10 mg In stock $ 72.00
25 mg In stock $ 139.00
50 mg In stock $ 233.00
100 mg In stock $ 346.00
1 mL * 10 mM (in DMSO) In stock $ 60.00
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Purity: 99.75%
Purity: 98.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.
Source
Synonyms (R)-1,2-Dimethoxyaporphine, (-)-Neferine
Molecular Weight 624.77
Formula C38H44N2O6
CAS No. 2292-16-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (40.01 mM)

TargetMolReferences and Literature

1. Zhang X , Liu Z , Xu B , et al. Neferine, an alkaloid ingredient in lotus seed embryo, inhibits proliferation of human osteosarcoma cells by promoting p38 MAPK-mediated p21 stabilization[J]. European Journal of Pharmacology, 2012, 677(1-3):47-54.

Related compound libraries

This product is contained In the following compound libraries：
Traditional Chinese Medicine Monomer Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Tumor Natural Product Library Anti-Gastroenteritis Natural Product Library Anti-Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Anti-Diabetic Compound Library Anti-Pancreatic Cancer Compound Library NF-κB Signaling Compound Library

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Lidocaine hydrochloride 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil Acacetin Quisinostat dihydrochloride Triglycidyl isocyanurate BAI1 FMAU Paederosidic acid

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Keywords

Neferine 2292-16-2 Apoptosis Autophagy NF-Κb NF-κB (R)-1,2-Dimethoxyaporphine Nuclear factor-κB Inhibitor inhibit Nuclear factor-kappaB 1,2-Dimethoxyaporphine (-)-Neferine inhibitor

 

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