Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 128.00 | |
5 mg | In stock | $ 277.00 | |
10 mg | In stock | $ 473.00 | |
25 mg | In stock | $ 759.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,380.00 | |
500 mg | In stock | $ 2,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 263.00 |
Description | 1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. |
Targets&IC50 | TNF-α:16.4 nM (IC50), IL-1β:10.8 nM (IC50) |
Source |
Synonyms | 7-O-Methylbaicalein, Baicalein-7-methylether |
Molecular Weight | 284.26 |
Formula | C16H12O5 |
CAS No. | 29550-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 50 mg/mL (175.9 mM)
You can also refer to dose conversion for different animals. More
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Negletein 29550-13-8 Apoptosis Immunology/Inflammation Interleukin IL Receptor NOS TNF inhibit TNF Receptor Interleukin Related TNFR outgrowth neuroprotectant Tumor Necrosis Factor Receptor Inhibitor growth,factor anti-inflammatory cell 7-O-Methylbaicalein nerve Baicalein-7-methylether PC12 neurite inhibitor