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Negletein

Catalog No. T2S0843   CAS 29550-13-8
Synonyms: 7-O-Methylbaicalein, Baicalein-7-methylether

1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.

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Negletein Chemical Structure
Negletein, CAS 29550-13-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 128.00
5 mg In stock $ 277.00
10 mg In stock $ 473.00
25 mg In stock $ 759.00
50 mg In stock $ 987.00
100 mg In stock $ 1,380.00
500 mg In stock $ 2,790.00
1 mL * 10 mM (in DMSO) In stock $ 263.00
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Purity: 99.92%
Purity: 98.54%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor.
Targets&IC50 TNF-α:16.4 nM (IC50), IL-1β:10.8 nM (IC50)
Source
Synonyms 7-O-Methylbaicalein, Baicalein-7-methylether
Molecular Weight 284.26
Formula C16H12O5
CAS No. 29550-13-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 50 mg/mL (175.9 mM)

TargetMolReferences and Literature

1. Phan, C., Sabaratnam, V., Bovicelli, P., Righi, G., & Saso, L. (2016). Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors, 42(6), 591-599. doi: 10.1002/biof.1296

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Miao medicine Compound Library Apoptosis Compound Library Bioactive Compounds Library Max Inhibitor Library Anti-infective Natural Product Library Pyroptosis Compound Library Flavonoid Natural Product Library Ferroptosis Compound Library Selected Plant-Sourced Compound Library

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Keywords

Negletein 29550-13-8 Apoptosis Immunology/Inflammation Interleukin IL Receptor NOS TNF inhibit TNF Receptor Interleukin Related TNFR outgrowth neuroprotectant Tumor Necrosis Factor Receptor Inhibitor growth,factor anti-inflammatory cell 7-O-Methylbaicalein nerve Baicalein-7-methylether PC12 neurite inhibitor

 

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