Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 52.00 | |
2 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 162.00 | |
10 mg | In stock | $ 228.00 | |
25 mg | In stock | $ 458.00 | |
50 mg | In stock | $ 659.00 | |
100 mg | In stock | $ 925.00 |
Description | Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. |
In vitro | Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR is a member of the G-protein coupled receptor (GPCR) family that is present in a majority of human pancreatic and colorectal cancers. It suggests that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1]. |
Molecular Weight | 1672.92 |
Formula | C78H121N21O20 |
CAS No. | 39379-15-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10mM
You can also refer to dose conversion for different animals. More
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Neurotensin 39379-15-2 GPCR/G Protein Neurotensin Receptor Inhibitor inhibit inhibitor