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Nilofabicin

Catalog No. T19642 CAS 934628-27-0

Synonyms: CG 0549, CG-0549, CG-400549, CG 400549, CG0549, CG400549

Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated acute.

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Nilofabicin, CAS 934628-27-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 80.00
25 mg	In stock	$ 133.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 328.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 98.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Nilofabicin (CG-400549) is a potent inhibitor of enoyl-(acyl-carrier-protein) reductase fall(FabI) and can be used in studies about the treatment of complicated acute.
Targets&IC50	S. aureus:0.5 μg/ml(MIC90)
In vitro	Nilofabicin had an MIC90 of 0.5 μg/ml for Staphylococcus aureus strains and was more potent than either linezolid or vancomycin. Among 203 strains of Staphylococcus aureus, the MICs of Nilofabicin were 0.06 to 1.0 μg/ml, with MIC(50) and MIC(90) values of 0.25 μg/ml each. All strains were susceptible to linezolid and quinupristin-dalfopristin (MICs, 0.25 to 2.0 μg/ml)[3].

Synonyms	CG 0549, CG-0549, CG-400549, CG 400549, CG0549, CG400549
Molecular Weight	340.44
Formula	C19H20N2O2S
CAS No.	934628-27-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (279.05 mM)

References and Literature

1. Kim BY, Sohn YT. Solid state of CG-400549, a novel FabI inhibitor: characterization, dissolution, transformation. Arch Pharm Res. 2011 May;34(5):775-9. doi: 10.1007/s12272-011-0511-7. Epub 2011 Jun 9. PubMed PMID: 21656363. 2. Bogdanovich T, Clark C, Kosowska-Shick K, Dewasse B, McGhee P, Appelbaum PC. Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents. Antimicrob Agents Chemother. 2007 Nov;51(11):4191-5. Epub 2007 Sep 17. PubMed PMID: 17875997; PubMed Central PMCID: PMC2151435. 3. Yum JH, Kim CK, Yong D, Lee K, Chong Y, Kim CM, Kim JM, Ro S, Cho JM. In vitro activities of CG400549, a novel FabI inhibitor, against recently isolated clinical staphylococcal strains in Korea. Antimicrob Agents Chemother. 2007 Jul;51(7):2591-3. Epub 2007 Apr 9. PubMed PMID: 17420210; PubMed Central PMCID: PMC1913239.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library ReFRAME Related Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Bacterial Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Nilofabicin 934628-27-0 Microbiology/Virology Antibacterial Antibiotic CG 0549 CG-0549 CG-400549 CG 400549 CG0549 inhibit CG400549 Inhibitor Bacterial inhibitor

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