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Nisoldipine

Catalog No. T0163   CAS 63675-72-9
Synonyms: BAY-k 5552

Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.

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Nisoldipine Chemical Structure
Nisoldipine, CAS 63675-72-9
Pack Size Availability Price/USD Quantity
100 mg In stock $ 41.00
500 mg In stock $ 58.00
1 g In stock $ 94.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.51%
Purity: 99.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
Targets&IC50 L-type Cav1.2:10 nM
Kinase Assay Binding experiments of electrophysiology: CHO cells expressing the subunit of the voltage-dependent L-type Ca2+ channel are cultrured in medium without serum in the presence of different concentrations of Nisoldipine. Then Ca2+ channel current elicited from a holding potential of -100 mV or -50 mV is recorded at room temperature with the whole-cell configuration of the patch-clamp method using the List EPC-7 patch-clamp amplifer and pClamp software. The concentration of competitor inhibiting 50% of the specific binding represents IC50.
Cell Research The myocytes are bathed in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, tail currents are recorded on repolarisations to -40mV. The myocytes are exposed to 10-100 mM Nisoldipine for 8-10 minutes. Then the whole-cell membrane currents are recorded using an EPC-7 amplifier.(Only for Reference)
Synonyms BAY-k 5552
Molecular Weight 388.41
Formula C20H24N2O6
CAS No. 63675-72-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 56 mg/mL (144.2 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 71 mg/mL (182.8 mM)

TargetMolReferences and Literature

1. Morel N, et al. Br J Pharmacol, 1998, 125(5), 12005-12012. 2. Missan S, et al. Br J Pharmacol, 2003, 140 (5), 863-870. 3. Sugawara H, et al. Hypertens Res, 1996, 19 (4), 223-228. 4. Iimuro Y, et al. Hepatology, 1996, 24(2), 391-397. 5. Splawski I, et al. Cell, 2004, 119 (1), 19-31. 6. Li W H, Huang K, Cai Y, et al. Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate[J]. Elife. 2021, 10: e67381.

TargetMolCitations

1. Li W H, Huang K, Cai Y, et al. Permeant Fluorescent Probes Visualize the Activation of SARM1 and Uncover an Anti-neurodegenerative Drug Candidate. Elife. 2021, 10: e67381. 2. Wang B, Pei J, Zhang H, et al.Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor.Interventions for emerging infectious diseases.2023, 16648714.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library NF-κB Signaling Compound Library Target-Focused Phenotypic Screening Library Mitochondria-Targeted Compound Library Immunology/Inflammation Compound Library Orally Active Compound Library Anti-Cancer Compound Library Anti-Hypertension Compound Library

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Keywords

Nisoldipine 63675-72-9 Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Reactive Oxygen Species Calcium Channel Ca2+ channels Inhibitor inhibit Ca channels BAY-k 5552 inhibitor

 

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