Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 41.00 | |
500 mg | In stock | $ 58.00 | |
1 g | In stock | $ 94.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. |
Targets&IC50 | L-type Cav1.2:10 nM |
Kinase Assay | Binding experiments of electrophysiology: CHO cells expressing the subunit of the voltage-dependent L-type Ca2+ channel are cultrured in medium without serum in the presence of different concentrations of Nisoldipine. Then Ca2+ channel current elicited from a holding potential of -100 mV or -50 mV is recorded at room temperature with the whole-cell configuration of the patch-clamp method using the List EPC-7 patch-clamp amplifer and pClamp software. The concentration of competitor inhibiting 50% of the specific binding represents IC50. |
Cell Research | The myocytes are bathed in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, tail currents are recorded on repolarisations to -40mV. The myocytes are exposed to 10-100 mM Nisoldipine for 8-10 minutes. Then the whole-cell membrane currents are recorded using an EPC-7 amplifier.(Only for Reference) |
Synonyms | BAY-k 5552 |
Molecular Weight | 388.41 |
Formula | C20H24N2O6 |
CAS No. | 63675-72-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 56 mg/mL (144.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 71 mg/mL (182.8 mM)
You can also refer to dose conversion for different animals. More
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Nisoldipine 63675-72-9 Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Reactive Oxygen Species Calcium Channel Ca2+ channels Inhibitor inhibit Ca channels BAY-k 5552 inhibitor