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Norathyriol

Catalog No. TN1990   CAS 3542-72-1

Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.

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Norathyriol Chemical Structure
Norathyriol, CAS 3542-72-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 152.00
5 mg In stock $ 373.00
10 mg In stock $ 556.00
25 mg In stock $ 896.00
50 mg In stock $ 1,220.00
100 mg In stock $ 1,650.00
1 mL * 10 mM (in DMSO) In stock $ 550.00
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Purity: 98.93%
Purity: 98.90%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability.
Targets&IC50 PPARα:92.8 μM (IC50), PPARβ:102.4 μM (IC50), PPARγ:153.5 μM (IC50)
In vitro Normal or IR L6 myotubes were incubated with Norathyriol (2.5 - 10 μM, 0.625 - 2.5 μM), mangiferin (10 - 40 μM, 2.5 - 10 μM) or rosiglitazone (20 μM) and/or 0.05 nM insulin for 24 h, respectively. The glucose consumption was assessed using the glucose oxidase method. Immunoblotting was performed to detect protein kinase B (PKB/Akt) and AMP-activated protein kinase (AMPK) phosphorylation in L6 myotubes cells. Norathyriol and mangiferin treatment alone increased the glucose consumption 61.9 and 56.3%, respectively, in L6 myotubes and made additional increasing with 0.05 nM insulin. In IR L6 myotubes, Norathyriol treatment made increasing with or without insulin, mangiferin treatment also made increasing but only when co-treated with insulin. Immunoblotting results showed that Norathyriol and mangiferin produced an increase of 1.9 - and 1.8-fold in the phosphorylation levels of the AMPK, but not in Akt[1]
Source
Molecular Weight 260.2
Formula C13H8O6
CAS No. 3542-72-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (249.81 mM)

TargetMolReferences and Literature

1. Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.Pharm Biol. 2014 Jan;52(1):68-73.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Tobacco Monomer Library Miao medicine Compound Library Angiogenesis related Compound Library Anti-Breast Cancer Compound Library Antioxidant Compound Library Kinase Inhibitor Library Polyphenolic Natural Product Library Anti-Tumor Natural Product Library Lipid Metabolism Compound Library

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Keywords

Norathyriol 3542-72-1 Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Metabolism PI3K/Akt/mTOR signaling Akt DNA/RNA Synthesis PPAR AMPK anti-bacterial Mangiferitin metabolite Mangifera anticancer Natural Antioxidant Glucosidase Inhibitor anti-inflammatory Peroxisome proliferator-activated receptors antimicrobial α-glucosidase inhibit inhibitor

 

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