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Norbinaltorphimine dihydrochloride

Catalog No. T12241   CAS 113158-34-2
Synonyms: nor-BNI dihydrochloride, Nor-BNI dihydrochloride, nor-Binaltorphimine dihydrochloride, Nor-Binaltorphimine dihydrochloride

Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.

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Norbinaltorphimine dihydrochloride Chemical Structure
Norbinaltorphimine dihydrochloride, CAS 113158-34-2
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.
In vitro Norbinaltorphimine dihydrochloride reversibly antagonizes the effects of κ agonists with pA2 values ranging from 10.2 to 10.4. However, it is important to note that Norbinaltorphimine dihydrochloride is much less potent as an antagonist at μ and δ receptors, where the pA2 values are 7.4-7.6 and 7.6-7.8, respectively[3].
In vivo In adolescent rats, Norbinaltorphimine dihydrochloride exhibits weak and inconsistent effects on THC-induced taste avoidance. Notably, the impact of Norbinaltorphimine dihydrochloride varies based on dose and trial, as it both attenuates and strengthens taste avoidance. However, these effects are limited, with no significant influence on the final one-bottle avoidance and no observable effects on the two-bottle preference test. Interestingly, Norbinaltorphimine dihydrochloride demonstrates no effect on THC-induced taste avoidance in adult rats as well[2].Furthermore, when administered as a pretreatment,Norbinaltorphimine dihydrochloride significantly attenuates stress-induced reinstatement of nicotine-conditioned place preference (CPP). However, it is important to note that Norbinaltorphimine dihydrochloride has no discernible effect on nicotine-primed reinstatement[1].
Synonyms nor-BNI dihydrochloride, Nor-BNI dihydrochloride, nor-Binaltorphimine dihydrochloride, Nor-Binaltorphimine dihydrochloride
Molecular Weight 734.71
Formula C40H45Cl2N3O6
CAS No. 113158-34-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (108.89 mM), sonification is recommended.

H2O: 20 mg/mL (27.22 mM), sonification is recommended.

TargetMolReferences and Literature

1. Jackson KJ, et al. Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology (Berl). 2013 Apr;226(4):763-8. 2. Flax SM, et al. Effect of norbinaltorphimine on ∆⁹-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology (Berl). 2015 Sep;232(17):3193-201. 3. Birch PJ, et al. Norbinaltorphimine: antagonist profile at kappa opioid receptors. Eur J Pharmacol. 1987 Dec 15;144(3):405-8.

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Keywords

Norbinaltorphimine dihydrochloride 113158-34-2 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Norbinaltorphimine nor-BNI Dihydrochloride nor-Binaltorphimine Dihydrochloride nor-BNI dihydrochloride nor-BNI Nor-BNI dihydrochloride Norbinaltorphimine Dihydrochloride nor-Binaltorphimine dihydrochloride Nor-Binaltorphimine dihydrochloride nor-Binaltorphimine inhibitor inhibit

 

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