store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice.
Pack Size | Availability | Price/USD | Quantity |
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1 mg | In stock | $ 34.00 | |
5 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry |
Description | Norbinaltorphimine dihydrochloride is a selective and potent κ opioid receptor antagonist that induces itch-associated responses in mice. |
In vitro | Norbinaltorphimine dihydrochloride reversibly antagonizes the effects of κ agonists with pA2 values ranging from 10.2 to 10.4. However, it is important to note that Norbinaltorphimine dihydrochloride is much less potent as an antagonist at μ and δ receptors, where the pA2 values are 7.4-7.6 and 7.6-7.8, respectively[3]. |
In vivo | In adolescent rats, Norbinaltorphimine dihydrochloride exhibits weak and inconsistent effects on THC-induced taste avoidance. Notably, the impact of Norbinaltorphimine dihydrochloride varies based on dose and trial, as it both attenuates and strengthens taste avoidance. However, these effects are limited, with no significant influence on the final one-bottle avoidance and no observable effects on the two-bottle preference test. Interestingly, Norbinaltorphimine dihydrochloride demonstrates no effect on THC-induced taste avoidance in adult rats as well[2].Furthermore, when administered as a pretreatment,Norbinaltorphimine dihydrochloride significantly attenuates stress-induced reinstatement of nicotine-conditioned place preference (CPP). However, it is important to note that Norbinaltorphimine dihydrochloride has no discernible effect on nicotine-primed reinstatement[1]. |
Synonyms | nor-BNI dihydrochloride, Nor-BNI dihydrochloride, nor-Binaltorphimine dihydrochloride, Nor-Binaltorphimine dihydrochloride |
Molecular Weight | 734.71 |
Formula | C40H45Cl2N3O6 |
CAS No. | 113158-34-2 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (108.89 mM), sonification is recommended.
H2O: 20 mg/mL (27.22 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Norbinaltorphimine dihydrochloride 113158-34-2 Endocrinology/Hormones GPCR/G Protein Neuroscience Opioid Receptor Norbinaltorphimine nor-BNI Dihydrochloride nor-Binaltorphimine Dihydrochloride nor-BNI dihydrochloride nor-BNI Nor-BNI dihydrochloride Norbinaltorphimine Dihydrochloride nor-Binaltorphimine dihydrochloride Nor-Binaltorphimine dihydrochloride nor-Binaltorphimine inhibitor inhibit