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Norepinephrine bitartrate monohydrate

Catalog No. T1064 CAS 108341-18-0

Synonyms: Levophed, Noradrenaline bitartrate monohydrate

Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.

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Norepinephrine bitartrate monohydrate Chemical Structure

Norepinephrine bitartrate monohydrate, CAS 108341-18-0

Pack Size	Availability	Price/USD
200 mg	In stock	$ 33.00
500 mg	In stock	$ 54.00
1 g	In stock	$ 85.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.8%

Purity: 98%

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Description	Norepinephrine bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator.
Targets&IC50	β1-adrenoceptor:5.37 μM(EC50)
In vitro	Noradrenaline modulates the gain of evoked activity, especially in sensory areas. Noradrenaline promotes long-term synaptic plasticity, in addition to these data emphasizing its short-term influence. Noradrenaline would signal ‘gross changes in the environment that produce sensory information strongly violating top-down expectations' and would, through an enhancement of ‘bottom-up' information processing at the expense of irrelevant ‘top-down' expectations, favor behavioral adjustment. [1] Noradrenaline modulates drive and energy and exerts a fine regulation of specific processes including learning, memory, sleep, arousal and adaptation. Noradrenaline system is intimately involved in a range of psychological processes which, when disrupted, lead to the expression of classifiable psychiatric disorders. Noradrenaline appears to be involved in a range of psychological processes, including arousal (vigilance), cognition, learning and sleep regulation, and also in regulating response to stressors which might initiate or exacerbate depressive symptomatology. Noradrenaline deficiency in this pathway may reduce concentration, affect working memory and cause psychomotor retardation, resulting in apathy and depression,while an increase in noradrenaline in this pathway is predicted to alleviate poor concentration, apathy and depression. [2] Noradrenaline effects are complex and depending on experimental conditions (ponto-medullary and medullary preparations) and species (rats or mice), exogenous Noradrenaline mainly facilitates or mainly inhibits the neonatal RRG, with a mixture of α1 facilitatory and α2 inhibitory effects. [3]
Cell Research	Norepinephrine (NE)is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

Synonyms	Levophed, Noradrenaline bitartrate monohydrate
Molecular Weight	337.28
Formula	C8H11NO3·C4H6O6·H2O
CAS No.	108341-18-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 31.9 mg/mL (100 mM)

DMSO: 31.9 mg/mL (100 mM)

References and Literature

1. Bouret S, et al. Trends Neurosci, 2005, 28(11), 574-582. 2. Brunello N, et al. Int Clin Psychopharmacol, 2003, 18(4), 191-202. 3. Hilaire G, et al. Auton Neurosci, 2006, 126-127, 320-331.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Coagulation and Anticoagulation Compound Library Anti-Obesity Compound Library

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Keywords

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