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Novokinin acetate

Catalog No. T23077L CAS T23077L

Synonyms: Novokinin acetate (358738-77-9 free base)

Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.

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Novokinin acetate, CAS T23077L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 237.00
5 mg	In stock	$ 533.00
10 mg	In stock	$ 768.00
25 mg	In stock	$ 1,190.00
50 mg	In stock	$ 1,580.00
100 mg	In stock	$ 2,160.00
1 mL * 10 mM (in DMSO)	In stock	$ 856.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Novokinin acetate exhibited an affinity for the AT2 receptor with Ki of 7 nM, and its antihypertensive and vasorelaxing activities were blocked by PD123319, an AT2 receptor antagonist.
Targets&IC50	AT2:7 nM(Ki)
In vitro	Novokinin relaxed a mesenteric artery isolated from the spontaneously hypertensive rat (SHR) at 10(-5) M, and reduced SHR blood pressure at a dose of 0.1 mg/kg (po.) emulsified in 30% egg yolk[1].
In vivo	The hypotensive effect of novokinin in normotensive mice was not observed in the AT2 receptor-knockout mice. Its antihypertensive and vasorelaxing activities in SHR were also blocked by CAY-10441, an antagonist of the IP receptor for prostaglandin I2 PGI2 suggesting that these activities are mediated by the AT2 receptor, followed by the prostaglandin I2-IP receptor pathway. Novokinin suppressed food intake after icv. or po. administration in mice. The anorexigenic activity was not observed in the AT2 receptor- knockout mice, but was observed in the AT 1 receptor-knockout mice. The anorexigenic activities of novokinin and angiotensin II were blocked by PD123319, and ONO-AE3-208, an antagonist of the EP4 receptor suggesting that the anorexigenic activities of the AT2 agonists are mediated by the PGE 2-EP4 receptor pathway downstream of the AT2 receptor. Novokinin given icv. in mice antagonized the antinociceptive effect of morphine[1].

Synonyms	Novokinin acetate (358738-77-9 free base)
Molecular Weight	856.02
Formula	C41H65N11O9
CAS No.	T23077L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13 mg/mL (15.19 mM)

References and Literature

1. Masaaki Yoshikawa, et al. The pharmacological effects of novokinin; a designed peptide agonist of the angiotensin AT2 receptor. Curr Pharm Des. 2013;19(17):3009-12.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Peptide Compound Library Endocrinology-Hormone Compound Library

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Keywords

Novokinin acetate T23077L Endocrinology/Hormones RAAS Novokinin acetate (358738-77-9 free base) Novokinin Acetate 358738-77-9 358738-77-9 free base inhibitor inhibit

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