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OPHIOPOGONIN D

Catalog No. T5701 CAS 945619-74-9

Synonyms: Calcium Channel, Nuclear factor-κB, Ca channels, Nuclear factor-kappaB, Ca2+ channels, inhibit, OPHIOPOGONIN D, Inhibitor, NF-κB, PPAR, Peroxisome proliferator-activated receptors

Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

OPHIOPOGONIN D, CAS 945619-74-9

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Purity: 98%

Biological Description

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Description

Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.

In vitro

OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process.

Synonyms	Calcium Channel, Nuclear factor-κB, Ca channels, Nuclear factor-kappaB, Ca2+ channels, inhibit, OPHIOPOGONIN D, Inhibitor, NF-κB, PPAR, Peroxisome proliferator-activated receptors
Molecular Weight	855.028
Formula	C44H70O16
CAS No.	945619-74-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Huang X , Wang Y , Zhang Z , et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs[J]. Biochemical and Biophysical Research Communications, 2017:S0006291X17311166.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Endocrinology-Hormone Compound Library Inhibitor Library Saccharide and Glycoside Natural Product Library Bioactive Compound Library Selected Plant-Sourced Compound Library

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