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OPHIOPOGONIN D

Catalog No. T5701   CAS 945619-74-9

Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.

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OPHIOPOGONIN D Chemical Structure
OPHIOPOGONIN D, CAS 945619-74-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 64.00
5 mg In stock $ 158.00
10 mg In stock $ 213.00
25 mg In stock $ 359.00
50 mg In stock $ 533.00
100 mg In stock $ 759.00
1 mL * 10 mM (in DMSO) In stock $ 237.00
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Purity: 99.75%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
In vitro OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process.
Molecular Weight 855.02
Formula C44H70O16
CAS No. 945619-74-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (35.09 mM)

TargetMolReferences and Literature

1. Huang X , Wang Y , Zhang Z , et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs[J]. Biochemical and Biophysical Research Communications, 2017:S0006291X17311166.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Inflammatory Traditional Chinese Medicine Compound Library Endocrinology-Hormone Compound Library Anti-Pancreatic Cancer Compound Library Anti-Breast Cancer Compound Library Anti-Liver Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Anti-Prostate Cancer Compound Library Traditional Mongolian Medicine Compound Library Pyroptosis Compound Library

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Keywords

OPHIOPOGONIN D 945619-74-9 DNA Damage/DNA Repair Endocrinology/Hormones Membrane transporter/Ion channel Metabolism NF-Κb NF-κB RAAS Calcium Channel PPAR Nuclear factor-κB Ca channels Nuclear factor-kappaB Ca2+ channels inhibit Inhibitor Peroxisome proliferator-activated receptors inhibitor

 

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