Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 158.00 | |
10 mg | In stock | $ 213.00 | |
25 mg | In stock | $ 359.00 | |
50 mg | In stock | $ 533.00 | |
100 mg | In stock | $ 759.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 237.00 |
Description | Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. |
In vitro | OPHIOPOGONIN D(OP-D) significantly inhibited Ang II induced NF-κB nuclear translocation, IκBα down-regulation and activation of pro-inflammatory cytokines (TNF-α, IL-6 and VCAM-1) by increasing the expression of CYP2J2/EETs and PPARα in HUVECs.?Furthermore, treatment with exogenous 11,12-EET attenuated endothelial inflammation induced by Ang II as evidenced by inhibited NF-κB nuclear translocation, increased IκBα expression and decreased inflammation factor level.?Finally, the activation of NF-κB nuclear translocation induced by Ang II was also markedly suppressed by fenofibrate.?Co-incubation with 6-(2-proparglyloxyphenyl) hexanoic acid (PPOH) and PPARα inhibitor GW6471 before drug treatment abolished the endothelium protective effects of OP-D.?Suggest that OP-D has the endothelial protective effect through activation of CYP2J and increasing EETs, and PPARα involves in this process. |
Molecular Weight | 855.02 |
Formula | C44H70O16 |
CAS No. | 945619-74-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (35.09 mM)
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OPHIOPOGONIN D 945619-74-9 DNA Damage/DNA Repair Endocrinology/Hormones Membrane transporter/Ion channel Metabolism NF-Κb NF-κB RAAS Calcium Channel PPAR Nuclear factor-κB Ca channels Nuclear factor-kappaB Ca2+ channels inhibit Inhibitor Peroxisome proliferator-activated receptors inhibitor