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Omberacetam

Catalog No. T7108   CAS 157115-85-0
Synonyms: SGS-111, Noopept, GVS-111

Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.

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Omberacetam Chemical Structure
Omberacetam, CAS 157115-85-0
Pack Size Availability Price/USD Quantity
2 mg In stock $ 30.00
5 mg In stock $ 47.00
10 mg In stock $ 72.00
25 mg In stock $ 138.00
50 mg In stock $ 225.00
100 mg In stock $ 328.00
200 mg In stock $ 493.00
500 mg In stock $ 788.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 98%
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Biological Description
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Description Omberacetam (Noopept) is a synthetic dipeptide that has been shown to produce positive nootropic and cognitive effects in animal models by a mechanism similar to other related racetam compounds.
In vitro The neuroprotective effect of noopept (added to the medium at 10 μM concentration, 72 hours before Аβ 25-35) was studied on Аβ 25-35-induced injury (5 μM for 24 h) in PC12 cells.?The ability of drug to protect the impairments of cell viability, calcium homeostasis, ROS level, mitochondrial function, tau phosphorylation and neurite outgrowth caused by Аβ 25-35 were evaluated.?Following the exposure of PC12 cells to Аβ 25-35 an increase of the level of ROS, intracellular calcium, and tau phosphorylation at Ser396 were observed;?these changes were accompanied by a decrease in cell viability and an increase of apoptosis.?Noopept treatment before the amyloid-beta exposure improved PC12 cells viability, reduced the number of early and late apoptotic cells, the levels of intracellular reactive oxygen species and calcium and enhanced the mitochondrial membrane potential.?In addition, pretreatment of PC12 cell with noopept significantly attenuated tau hyperphosphorylation at Ser396 and ameliorated the alterations of neurite outgrowth evoked by Аβ25-35[1].
In vivo Noopept eliminated the manifestations of learned helplessness after long-term (21-day) treatment by increasing the percent of trained animals[2].
Cell Research PC12 cells were cultured routinely at 37°C in DMEM medium, supplemented with 10% fetal bovine serum (FBS), 5% horse serum, 2 mM L-glutamine, 50 μg/ml gentamicin. To induce PC12 differentiation, NGF (50 ng/ml) was added to the DMEM containing 1% FBS, followed by a 5-day incubation. Differentiated PC12 (dPC12) cells were pretreated with noopept at concentration of 10 μM for 72 h, then cells were rinsed with the medium and exposed to amyloid-β-peptide (Аβ25–35;5 μM) for 24 h. Untreated cells were used as control[1].
Animal Research Experiments were carried out on adult outbred albino male rats (n=376; 250-300 g) kept under vivarium conditions with 12-h light period with free access to water and standard food. The operant training was performed in a modified setup for active avoidance conditioning under conditions of uncertain environment.The animals were intraperitoneally injected (1 ml/kg) with noopept (0.1, 0.5, and 1.0 mg/kg) and piracetam (100, 300, and 500 mg/kg; reference drug), afobazol (1, 5, and 10 mg/kg), and buspiron (0.5, 1.0, and 5.0 mg/kg; reference drug) and diazepam (0.05, 0.1, and 0.5 mg/kg; reference drug). Control rats were injected with the same volume of saline. Stability of active avoidance behavior was tested after 48 h and 7 days. The animals with learned helplessness neurosis were injected with noopept and afobazol for 21 days, after which stability of the active avoidance behavior was repeatedly tested[2].
Synonyms SGS-111, Noopept, GVS-111
Molecular Weight 318.37
Formula C17H22N2O4
CAS No. 157115-85-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (314.10 mM)

TargetMolReferences and Literature

1. Ostrovskaya R U , Vakhitova Y V , Uliyana Sh Kuzmina…. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation[J]. Journal of Biomedical Science, 2014, 21(1). 2. Uyanaev A A , Fisenko V P . Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis[J]. Bulletin of Experimental Biology & Medicine, 2006, 142(2):202-204.

Related compound libraries

This product is contained In the following compound libraries:
Neuronal Signaling Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Neurotransmitter Receptor Compound Library ReFRAME Related Library Human Metabolite Library Bioactive Compound Library NO PAINS Compound Library Anti-Cancer Compound Library

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Keywords

Omberacetam 157115-85-0 Membrane transporter/Ion channel Neuroscience Others iGluR Inhibitor SGS-111 Ionotropic glutamate receptors Noopept GVS 111 inhibit SGS 111 GVS111 GVS-111 SGS111 inhibitor

 

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