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Omeprazole

Catalog No. T0757 CAS 73590-58-6

Synonyms: Losec, Prilosec, H 16868, Antra

Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).

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Omeprazole, CAS 73590-58-6

Pack Size	Availability	Price/USD
50 mg	In stock	$ 40.00
100 mg	In stock	$ 48.00
200 mg	In stock	$ 63.00
500 mg	In stock	$ 97.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 97.61%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
In vitro	Omeprazole transiently alters the kinetic properties of parietal cells in rabbits, leading to premature cell death and expedited growth. By inhibiting H(+)-K(+)-ATPase, omeprazole enhances the clearance of degenerative changes and macrophage-mediated removal of parietal cells, as well as promoting the increase of progenitor cells at the apical ridge.
In vivo	Omeprazole diminishes the activation of osteoclasts in vitro, while enhancing the activation of osteoblasts, leading to osteosclerosis-like effects to some extent. In human hepatocellular carcinoma cells, omeprazole induces the transcription of reporter genes through dioxin receptor elements recognized by ligand-activated aryl hydrocarbon receptors. It effectively induces the expression of cytochrome P4501A1 mRNA in primary human hepatocytes, but this induction is not detected in mouse primary hepatocytes. Omeprazole significantly suppresses the basal natural killer (NK) activity in splenocytes (SC) from untreated CD2F1 mice. It exerts rapid and robust effects on various types of cytotoxic lymphocytes, ranging from the inhibition of cytotoxicity to irreversible cellular damage. Furthermore, omeprazole notably inhibits the cytotoxicity of all types of effector cells after 30 minutes of incubation.

Synonyms	Losec, Prilosec, H 16868, Antra
Molecular Weight	345.42
Formula	C17H19N3O3S
CAS No.	73590-58-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1eq. HCl: 17.3 mg/mL (50 mM)

DMSO: 34.5 mg/mL (100 mM)

References and Literature

1. Dzeletovic N, et al. J Biol Chem, 1997, 272(19), 12705-12713. 2. Scaringi L, et al. Scand J Immunol, 1996, 44(3), 204-214. 3. Hyun JJ, et al. Int J Mol Med, 2010, 26(6), 877-883. 4. Karam SM, et al. Am J Physiol, 1994, 266(4 Pt 1), G745-758. 5. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches[J]. RSC Advances. 2018 Jan 8(10): 5286-5297.

Citations

1. Kang D, Pang X, Lian W, et al. Discovery of VEGFR2 inhibitors by integrating naïve Bayesian classification, molecular docking and drug screening approaches. RSC Advances. 2018 Jan 8(10): 5286-5297.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Membrane Protein-targeted Compound Library Inhibitor Library Drug Repurposing Compound Library Anti-COVID-19 Compound Library Anti-Bacterial Compound Library Pediatric Drug Library ReFRAME Related Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Omeprazole 73590-58-6 Autophagy Membrane transporter/Ion channel Metabolism Microbiology/Virology Phospholipase Proton pump Antibacterial inhibit Inhibitor Losec Prilosec Bacterial Proton Pump H 16868 H-16868 H16868 Antra inhibitor

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