Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as intraocular pressure (IOP)-lowering drug.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 8-10 weeks | $ 789.00 | |
100 mg | 8-10 weeks | $ 1,280.00 |
Description | Omidenepag isopropyl is converted to the active product Omidenepag during corneal penetration. Omidenepag isopropyl is a selective EP2 receptor agonist. Omidenepag isopropyl displays only a weak affinity for EP1, EP2, and FP receptors. Omidenepag isopropyl is under development for the treatment of glaucoma as intraocular pressure (IOP)-lowering drug. |
In vivo | Omidenepag isopropyl, when hydrolyzed in the eye, becomes Omidenepag (OMD), an EP2 receptor agonist demonstrating a pronounced ocular hypotensive effect across both normotensive and hypertensive animal models[1]. This compound has shown significant, dose-dependent intraocular pressure (IOP) reduction in normotensive monkeys at concentrations of 0.0001%, 0.001%, and 0.01%, achieving mean maximal IOP reductions of 2.4 ± 0.6, 7.6 ± 1.7, and 13.3 ± 1.2 mm Hg, respectively. In a study, either Omidenepag isopropyl, Xalatan, or a vehicle was administered topically to one eye of normotensive monkeys, with the alterations in IOP measured against a predosing baseline from day 1. Notably, for concentrations of 0.001% and 0.01%, significant reductions in IOP were observed at the outset of day 7. Moreover, in hypertensive monkeys, Omidenepag isopropyl was found to lower IOP by enhancing both trabecular and uveoscleral outflow[2]. |
Molecular Weight | 520.6 |
Formula | C26H28N6O4S |
CAS No. | 1187451-19-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Omidenepag isopropyl 1187451-19-9 GPCR/G Protein Immunology/Inflammation Prostaglandin Receptor inhibitor inhibit