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Oroxylin A

Catalog No. T6S1315 CAS 480-11-5

Synonyms: 6-Methoxybaicalein, Baicalein 6-methyl ether

1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production via modulation of LAP/LIP/CHOP in leukemia cell lines, which could providing a therapeutic strategy for RAS. 3. Oroxylin A inhibits UCP2s triggers the MPTP opening, and promotes the apoptosis in CaCo-2 cells; uncoupling protein 2 plays a key role in mitochondrial apoptotic pathway. 4. Oroxylin A inhibits N1ICD translocating to the nucleus and binding to epithelial-mesenchymal transition-related transcription factor Snail, thus suppressing the invasion and migration of MCF-7 cells. 5. Oroxylin A improves the sensitivity of K562/ADM cells by increasing apoptosis in leukemic cells and decreasing the expression of CXCR4 and PI3K/Akt/NF-κB pathway, and probably served as a most promising agent for CML treatment.

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Oroxylin A, CAS 480-11-5

Pack Size	Availability	Price/USD	Quantity
20 mg	In stock	$ 140.00
1 mL * 10 mM (in DMSO)	In stock	$ 80.00

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Purity: 99.67%

Purity: 99.55%

Purity: 99.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Bignoniaceae > Oroxylum

Synonyms	6-Methoxybaicalein, Baicalein 6-methyl ether
Molecular Weight	284.26
Formula	C16H12O5
CAS No.	480-11-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 32 mg/mL

References and Literature

1. Ku S K , Lee I C , Bae J S . Antithrombotic activities of oroxylin A in vitro and in vivo[J]. Archives of Pharmacal Research, 2013, 37(5):679-86. 2. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin[J]. European Journal of Pharmaceutical Sciences. 2021: 105786.

Citations

1. Kuang Y, Chai Y, Xu L, et al. Glabrone as a specific UGT1A9 probe substrate and its application in discovering the inhibitor glycycoumarin. European Journal of Pharmaceutical Sciences. 2021: 105786. 2. Ni Z, Ma H, Li X, et al.Wogonin alleviates BaP‐induced DNA damage and oxidative stress in human airway epithelial cells by dual inhibiting CYP1A1 activity and expression.Environmental Toxicology.2023

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Miao medicine Compound Library Bioactive Compound Library Anti-infective Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Glycometabolism Compound Library Food as Medicine Compound Library Traditional Chinese Medicine Monomer Library Anti-Viral Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Oroxylin A 480-11-5 Autophagy Chromatin/Epigenetic Metabolism Microbiology/Virology HIF/HIF Prolyl-Hydroxylase Virus Protease HIF-PH HIFs Inhibitor 6-Methoxybaicalein inhibit Hypoxia-inducible factors Baicalein 6-methyl ether inhibitor

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