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Oxolinic acid

Catalog No. T1233 CAS 14698-29-4

Synonyms: Emyrenil, Nidantin, NSC 110364, Dioxacin, Urinox

Oxolinic acid (Nidantin) is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Oxolinic acid, CAS 14698-29-4

Pack Size	Availability	Price/USD
250 mg	In stock	$ 34.00
500 mg	In stock	$ 46.00
1 g	In stock	$ 48.00

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Purity: 98.39%

Purity: 98.15%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oxolinic acid (Nidantin) is a synthetic antimicrobial related to NALIDIXIC ACID and used in URINARY TRACT INFECTIONS.
Targets&IC50	Dopamine uptake:4.3 μM
In vitro	Oxolinic acid, a quinolone antibacterial agent, inhibits reversibly the ATP-dependent replicative DNA synthesis in permeable cell systems as well as in cellophane disk lysates[4]. It also inhibits bacterial DNA gyrase but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 μg/ml[5][6][7].
In vivo	The antimicrobial agent oxolinic acid, injected i.p. in mice, induces a dose dependent increase in locomotor activity. the stimulant locomotor effect of oxolinic acid depends on the blockade of the neuronal dopamine uptake complex[2].

Synonyms	Emyrenil, Nidantin, NSC 110364, Dioxacin, Urinox
Molecular Weight	261.23
Formula	C13H11NO5
CAS No.	14698-29-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 2.5 mM

References and Literature

1. Izawa A, et al. Antimicrob Agents Chemother. 1980, 18(1):41-44. 2. Garcia de Mateos-Verchere J, et al. Eur Neuropsychopharmacol. 1998, 8(4):255-259. 3. O'Connor MB, et al. J Mol Biol. 1985, 181(4):545-550. 4. Staudenbauer WL. Eur J Biochem. 1976, 62(3):491-497. 5. Drlica K, et al. Microbiol Mol Biol Rev. 1997, 61(3):377-392.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library NO PAINS Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Anti-Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Oxolinic acid 14698-29-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair GPCR/G Protein Microbiology/Virology Neuroscience Dopamine Receptor DNA/RNA Synthesis Antibacterial Antibiotic Emyrenil dopamine inhibit DNA/RNA Bacterial Nidantin NSC-110364 Inhibitor uptake antimicrobial NSC 110364 NSC110364 urinary Dioxacin infections tract synthesis Urinox inhibitor

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