Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 43.00 | |
5 g | In stock | $ 52.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone. |
In vitro | A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2]. |
In vivo | In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2]. |
Cell Research | Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production. (Only for Reference) |
Synonyms | KAHSCREEN BZ-3, Benzophenone 3, Eusolex 4360, Escalol 567 |
Molecular Weight | 228.24 |
Formula | C14H12O3 |
CAS No. | 131-57-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 197.2 mM
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Oxybenzone 131-57-7 Apoptosis Autophagy Metabolism Retinoid Receptor sun Retinoid X receptors RAR/RXR Inhibitor Retinoic acid receptors KAHSCREEN BZ-3 inhibit filter Benzophenone 3 Eusolex 4360 Benzophenone3 blood-brain placental barriers neuronal Benzophenone-3 Escalol 567 cells inhibitor