Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAT-1251 Hydrochloride is a potent, selective and oral inhibitor of lysyl oxidase-like 2 (LOXL2)(hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM , respectively),
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | PAT-1251 Hydrochloride is a potent, selective and oral inhibitor of lysyl oxidase-like 2 (LOXL2)(hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM , respectively), |
Targets&IC50 | LOXL3 (human):1.17 μM , LOXL2 (dog):0.16 μM , LOXL2 (rat):0.12 μM , LOXL2 (mouse):0.10 μM , LOXL2 (human):0.71 μM |
In vitro | PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with <10% inhibition at 10 μM[1]. |
Molecular Weight | 435.8 |
Formula | C18H18ClF4N3O3 |
CAS No. | 2098884-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PAT-1251 Hydrochloride 2098884-53-6 Others PAT1251 Hydrochloride PAT 1251 Hydrochloride inhibitor inhibit