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PD 128042

Catalog No. T22665 CAS 114289-47-3

Synonyms: CI 976

PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multiple membrane trafficking steps.

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PD 128042, CAS 114289-47-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
2 mg	In stock	$ 61.00
5 mg	In stock	$ 87.00
10 mg	In stock	$ 129.00
25 mg	In stock	$ 279.00
50 mg	In stock	$ 519.00
100 mg	In stock	$ 752.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.44%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD 128042 (CI 976) is a potent orally active and selective ACAT inhibitor(IC50: 73 nM) and a potent lysophospholipid acyltransferase(LPAT) inhibitor. CI 976 inhibits Golgi-associated LPAT activity (IC50: 15 μM) and multiple membrane trafficking steps.
Targets&IC50	Golgi-associated LPAT:15 μM, ACAT:73 nM
In vitro	In the chronic cholesterol-fed rat model, CI 976 decreases non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol in rats with pre-established dyslipidemia[4].

Synonyms	CI 976
Molecular Weight	393.56
Formula	C23H39NO4
CAS No.	114289-47-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/ml(63.52 mM)

DMF: 25 mg/ml(63.52 mM)

Ethanol: 25 mg/ml(63.52 mM)

References and Literature

1. Chambers K, et al. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. J Cell Sci. 2005;118(Pt 14):3061-3071. 2. O'Brien PM, et al. Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. J Med Chem. 1994;37(12):1810-1822. 3. Drecktrah D, et al. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol Biol Cell. 2003;14(8):3459-3469. 4. Krause BR, et al. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J Lipid Res. 1993;34(2):279-294.

Citations

1. Luo W, Chen L, Sun H, et al.Soat2 inhibitor avasimibe alleviates acute pancreatitis by suppressing acinar cell ferroptosis.Naunyn-Schmiedeberg's Archives of Pharmacology.2024: 1-11.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Metabolism Compound Library Lipid Metabolism Compound Library ReFRAME Related Library Bioactive Compound Library Orally Active Compound Library Bioactive Compounds Library Max

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Nevanimibe hydrochloride YM17E Glabrol PF-07202954 Lecimibide YM-750 2-Furoic acid RP-64477

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Keywords

PD 128042 114289-47-3 Metabolism Acyltransferase CI 976 inhibit oral CI-976 Diacylglycerol acyltransferase transferase secretory PD128042 LPAT PD-128042 acyl-CoA:cholesterol acyltransferase mono- acylglycerol acyltransferase endocytic membrane trafficking pathway ACAT CI976 Diglyceride acyltransferase Inhibitor inhibitor

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