-20℃ 3 years powder
-80℃ 2 years in solvent
PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | 64.00 | |
5 mg | In stock | 114.00 | |
10 mg | In stock | 182.00 | |
25 mg | In stock | 359.00 | |
50 mg | In stock | 642.00 | |
100 mg | In stock | 1100.00 | |
1 mL * 10 mM (in DMSO) | In stock | 121.00 |
Description | PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1. |
Targets&IC50 | PD-1/PD-L1 :ic50 0.018μM, |
In vitro | BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1]. |
Kinase Assay | All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and 0.05% (v/v) Tween-20. For the PD-l-Ig/PD-Ll-His binding assay, inhibitors are pre-incubated with PD-Ll-His (10 nM final) for 15 m in 4 μL of assay buffer, followed by addition of PD-l-Ig (20 nM final) in 1 μL of assay buffer and further incubation for 15 m. PD-L1 from either human, cyno, or mouse are used. HTRF detection is achieved using europium crypate-labeled anti- Ig (1 nM final) and allophycocyanin (APC) labeled anti-His (20 nM final). Antibodies are diluted in HTRF detection buffer and 5 μL is dispensed on top of binding reaction. The reaction mixture is allowed to equilibrate for 30 minutes and signal (665 nm/620 nm ratio) is obtained using an En Vision fluorometer. Additional binding assays are established between PD-1-Ig/PD-L2-His (20, 5 nM, respectively), CD80-His/PD-Ll-Ig (100, 10 nM, respectively) and CD80-His/CTLA4-Ig (10, 5 nM, respectively). |
Synonyms | BMS-202, PD-1/PD-L1 inhibitor 2 |
Purity | 98.00% |
Appearance | solid |
Molecular Weight | 419.52 |
Formula | C25H29N3O3 |
CAS No. | 1675203-84-5 |
-20℃ 3 years powder
-80℃ 2 years in solvent
DMSO: 76 mg/mL (181.2 mM)
Ethanol: 83 mg/mL (197.85 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Safe and effective drug dosing is necessary, regardless of its purpose of administration. Learn More
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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.