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PD1-PDL1 inhibitor 2

Catalog No. T3146 CAS 1675203-84-5

Synonyms: BMS-202, PD-1/PD-L1 inhibitor 2

Purity 98.54% Datasheet MSDS

PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1.

PD1-PDL1 inhibitor 2, CAS 1675203-84-5

Pack Size	Availability	Price/USD
2 mg	In stock	64.00
5 mg	In stock	114.00
10 mg	In stock	182.00
25 mg	In stock	359.00
50 mg	In stock	642.00
100 mg	In stock	1100.00
1 mL * 10 mM (in DMSO)	In stock	121.00

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Purity 97.92%

HNMR HPLC COA Datasheet MSDS

Purity 98.54%

HNMR HPLC COA Datasheet MSDS

Purity 98.00%

HNMR COA Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction, extracted from patent WO/2015034820 A1.
Targets&IC50	PD-1/PD-L1 :ic50 0.018μM,
In vitro	BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1].
Kinase Assay	All binding studies are performed in an HTRF assay buffer consisting of dPBS supplemented with 0.1% (with v) bovine serum albumin and 0.05% (v/v) Tween-20. For the PD-l-Ig/PD-Ll-His binding assay, inhibitors are pre-incubated with PD-Ll-His (10 nM final) for 15 m in 4 μL of assay buffer, followed by addition of PD-l-Ig (20 nM final) in 1 μL of assay buffer and further incubation for 15 m. PD-L1 from either human, cyno, or mouse are used. HTRF detection is achieved using europium crypate-labeled anti- Ig (1 nM final) and allophycocyanin (APC) labeled anti-His (20 nM final). Antibodies are diluted in HTRF detection buffer and 5 μL is dispensed on top of binding reaction. The reaction mixture is allowed to equilibrate for 30 minutes and signal (665 nm/620 nm ratio) is obtained using an En Vision fluorometer. Additional binding assays are established between PD-1-Ig/PD-L2-His (20, 5 nM, respectively), CD80-His/PD-Ll-Ig (100, 10 nM, respectively) and CD80-His/CTLA4-Ig (10, 5 nM, respectively).

Synonyms	BMS-202, PD-1/PD-L1 inhibitor 2
Purity	98.00%
Appearance	solid
Molecular Weight	419.52
Formula	C25H29N3O3
CAS No.	1675203-84-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 76 mg/mL (181.2 mM)

Ethanol: 83 mg/mL (197.85 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Louis S. Chupak, et al. Compounds useful as immunomodulators. WO 2015034820 A1

Related Compound Libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Apoptosis Compound Library Immunology/Inflammation Compound Library Cell cycle related Compound Library

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