Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 129.00 | |
5 mg | In stock | $ 316.00 | |
10 mg | In stock | $ 482.00 | |
25 mg | In stock | $ 789.00 | |
50 mg | In stock | $ 1,080.00 | |
100 mg | In stock | $ 1,480.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 347.00 |
Description | PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4, IC50 value = 84 nM). |
Targets&IC50 | PDK4:84 nM |
In vitro | PDK4-IN-1 hydrochloride treatment significantly impedes the proliferation of human colon cancer cell lines, HCT116 and RKO. The colony formation efficiency in HCT116 and RKO cells Is significantly reduced after treatment of PDK4-IN-1[1]. PDK4-IN-1 (Compound 8c; 10-50 μM; 24 hours; HCT116 and RKO cells) treatment dose-dependently increased apoptosis. PDK4-IN-1 decreases the expression of BCL-xL and increases the expression of BAX. Cleavage of PARP1 and caspase 3 are increased by PDK4-IN-1[1]. |
In vivo | PDK4-IN-1 (C57BL/6J mice) treatment significantly improves glucose tolerance[1]. Pre-incubation with PDK4-IN-1 (compound 8c) dose-dependently inhibits the release of β-hexosaminidase from IgE/antigen-activated BMMCs, |
Molecular Weight | 393.87 |
Formula | C22H20ClN3O2 |
CAS No. | 2310262-11-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (317.36 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PDK4-IN-1 hydrochloride 2310262-11-2 Apoptosis PI3K/Akt/mTOR signaling PDK inhibit anti-allergic Pyruvate dehydrogenase kinase PDHE1α antidiabetic PDK4-IN-1 Hydrochloride p53 BCL-xL PARP1 caspase-3 BAX Inhibitor p-Akt PDK4 PDK4 IN 1 hydrochloride PDK4IN1 hydrochloride PDK-4-IN-1 hydrochloride PDHK metabolites PDH kinase anticancer inhibitor