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PEPA

Catalog No. T12406 CAS 141286-78-4

PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

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PEPA, CAS 141286-78-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 47.00
5 mg	In stock	$ 77.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 253.00
50 mg	In stock	$ 495.00
100 mg	In stock	$ 737.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 95.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.

Molecular Weight	402.44
Formula	C16H16F2N2O4S2
CAS No.	141286-78-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (124.24 mM), Sonification is recommended.

References and Literature

1. Sekiguchi M, et al. Pharmacological detection of AMPA receptor heterogeneity by use of two allosteric potentiators in rat hippocampal cultures. Br J Pharmacol. 1998 Apr;123(7):1294-303. 2. Ahmed AH, et al. Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry. 2010 Apr 6;49(13):2843-50. 3. Yamada D, et al. Facilitating actions of an AMPA receptor potentiator upon extinction of contextually conditioned fear response in stressed mice. Neurosci Lett. 2011 Jan 25;488(3):242-6. 4. Zhang QG, et al. Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia. Hippocampus. 2010 Jan;20(1):65-77.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library NO PAINS Compound Library Ion Channel Inhibitor Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max

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Keywords

PEPA 141286-78-4 Membrane transporter/Ion channel Neuroscience iGluR inhibit Inhibitor Ionotropic glutamate receptors inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.