Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | Inquiry | $ 1,520.00 |
Description | PF-04217903 phenolsulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met). |
Targets&IC50 | c-Met (human):ki:4.8 nM |
In vitro | PF-04217903 phenolsulfonate inhibits proliferation of c-Met–amplified human GTL-16 gastric carcinoma and H1993 NSCLC cells with IC50 values of 12 and 30 nM, respectively[1]. |
In vivo | PF-04217903 phenolsulfonate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 phenolsulfonate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors.PF-04217903 phenolsulfonate dose dependently inhibits c-Met, Gab-1, Erk1/2, and AKT phosphorylation and induced apoptosis (cleaved caspase-3) in U87MG xenograft tumors at all dose levels.[1]. |
Molecular Weight | 546.56 |
Formula | C25H22N8O5S |
CAS No. | 1159490-85-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-04217903 phenolsulfonate 1159490-85-3 Tyrosine Kinase/Adaptors c-Met/HGFR PF04217903 phenolsulfonate PF 04217903 phenolsulfonate inhibitor inhibit