Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 43.00 | |
10 mg | In stock | $ 61.00 | |
25 mg | In stock | $ 89.00 | |
50 mg | In stock | $ 133.00 | |
100 mg | In stock | $ 225.00 | |
200 mg | In stock | $ 397.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | PF-06447475 is a highly effective, specific, brain penetrant LRRK2 inhibitor with IC0 of 3/11 nM for wild type LRRK2 and G2019S LRRK2 respectively. |
Targets&IC50 | LRRK2 (G2019S):11nM, LRRK2:3nM |
In vitro | In the macrophage cell line Raw264.7, PF-06447475 inhibits endogenous LRRK2 kinase activity with IC50 of <10 nM. [2] In astrocytes, PF-06447475 rescues LRRK2 mutation-induced defects in lysosomal morphology and function. [3] |
In vivo | In G2019S BAC-transgenic mice, PF-06447475 (100 mg/kg, p.o.) inhibits pS935 and pS1292 phosphorylation of LRRK2 with IC50 of 103 nM and 21 nM, respectively. [1] In G2019S-LRRK2 rats, PF-06447475 (30 mg/kg, p.o.) blocks α-synuclein-induced dopaminergic neurodegeneration and attenuates neuroinflammation associated with G2019S-LRRK2 expression. [2] |
Molecular Weight | 305.33 |
Formula | C17H15N5O |
CAS No. | 1527473-33-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15.3 mg/mL (50 mM)
You can also refer to dose conversion for different animals. More
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PF-06447475 1527473-33-1 Autophagy LRRK2 Inhibitor Leucine-rich repeat kinase 2 inhibit PF06447475 PF 06447475 inhibitor