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PF-CBP1

Catalog No. T3973 CAS 1962928-21-7

PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM).

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PF-CBP1, CAS 1962928-21-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 110.00
25 mg	In stock	$ 216.00
50 mg	In stock	$ 391.00
100 mg	In stock	$ 582.00
1 mL * 10 mM (in DMSO)	In stock	$ 63.00

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Purity: 99.91%

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Description	PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM).
Targets&IC50	p300 BD:363 nM, CREBBP:125 nM
In vitro	PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson's disease. It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC. PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high.
Cell Research	Cells are pretreated with the probes PF-CBP1, ISOX-INACT, or ISOX-DUAL starting at 10 μM concentrations, and then serially diluted to 0.1 μM. After 30 min, the cells are treated with LPS to induce gene transcription and the expression levels of interleukin-6 (IL-6), IL-1β, and interferon-β (IFN-β)(which are known to be induced after 4 h of LPS exposure) are analyzed by RT-PCR. Probe PF-CBP1 moderately reduces LPS-induced IL-6 and IFN-β expression at 10 μM, and a decrease in IL-1β expression is evident at 3 μM.  (Only for Reference)

Molecular Weight	488.62
Formula	C29H36N4O3
CAS No.	1962928-21-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL

References and Literature

1. Eugene L, et al. Chem Biol. 2015, 22(12):1588-1596.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Highly Selective Inhibitor Library Histone Modification Compound Library Epigenetics Compound Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library PPI Inhibitor Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

PF-CBP1 1962928-21-7 Chromatin/Epigenetic Epigenetic Reader Domain PFCBP1 PF-CBP-1 Inhibitor PF CBP1 inhibit inhibitor

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