Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 59.00 | |
25 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 198.00 | |
100 mg | In stock | $ 369.00 | |
200 mg | In stock | $ 479.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | PF-CBP1 hydrochloride (PF-CBP1 HCl) is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively. |
Targets&IC50 | CREBBP:125nM, p300/CBP:363nM |
In vitro | PF-CBP1 modulates key inflammatory genes in primary macrophages. PF-CBP1 down regulates RGS4 in neurons, a target linked to Parkinson's disease.It is 139-fold selective over BRD4 in the biochemical assays and >105-fold selective by ITC.PF-CBP1 is also a potent inhibitor of EP300 and possesses no cytotoxicity in macrophages, and hepatotoxicity in cell-based models as long as the concentration is not very high[1]. |
Synonyms | PF-CBP1 HCl |
Molecular Weight | 525.08 |
Formula | C29H37ClN4O3 |
CAS No. | 2070014-93-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PF-CBP1 hydrochloride 2070014-93-4 Chromatin/Epigenetic Epigenetic Reader Domain Histone Acetyltransferase parkinson's disease HATs cortical inflammatory HAT PF CBP1 hydrochloride PF-CBP1 Hydrochloride inhibit RGS4 epilepsy PF-CBP1 PFCBP1 hydrochloride Inhibitor PF-CBP1 HCl neurological disorder PF-CBP-1 hydrochloride neuron inhibitor