Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 656.00 | |
5 mg | In stock | $ 1,290.00 | |
10 mg | In stock | $ 1,730.00 | |
25 mg | In stock | $ 2,590.00 | |
50 mg | In stock | $ 3,480.00 | |
100 mg | In stock | $ 4,720.00 |
Description | PI3Kα/mTOR-IN-1 is a potent dual inhibitor of PI3Kα/mTOR. PI3Kα/mTOR-IN-1 shows an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 12.5 nM and 10.6 nM for mTOR and PI3Kα in a cell free assay , respectively. |
Targets&IC50 | mTOR:10.6 nM (ki), PI3Kα:12.5 nM (ki), PI3Kα:7 nM (Cell Assay) |
In vitro | PI3Kα/mTOR-IN-1 exhibited excellent kinase selectivity from Pfizer’s in-house kinase selectivity panel of 43 kinases[1]. |
In vivo | PI3Kα/mTOR-IN-1 exhibited exhibited moderate clearance, moderate Vdss, T1/2 of 0.9 h, and good oral bioavailability[1]. |
Molecular Weight | 310.35 |
Formula | C16H18N6O |
CAS No. | 1013098-90-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11 mg/mL (35.44 mM)
You can also refer to dose conversion for different animals. More
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PI3Kα/mTOR-IN-1 1013098-90-2 PI3K/Akt/mTOR signaling PI3K mTOR PI3Kα/mTORIN1 PI3Kalpha/mTOR-IN-1 PI3Kα/mTOR IN 1 PI3Ka/mTOR-IN-1 PI-3Kα/mTOR-IN-1 inhibitor inhibit