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PI3K/mTOR Inhibitor-2

Catalog No. T12459 CAS 1848242-58-9

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PI3K/mTOR Inhibitor-2 Chemical Structure

PI3K/mTOR Inhibitor-2, CAS 1848242-58-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 89.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 396.00
25 mg	In stock	$ 665.00
50 mg	In stock	$ 947.00
100 mg	In stock	$ 1,280.00
500 mg	In stock	$ 2,570.00
1 mL * 10 mM (in DMSO)	In stock	$ 258.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.
Targets&IC50	mTOR:4.7 nM, PI3Kγ:1 nM, PI3Kα:3.4 nM, PI3Kβ:34 nM, PI3Kδ:16 nM
In vitro	PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile[1].
In vivo	PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model[1].

Molecular Weight	478.86
Formula	C20H13ClF2N4O4S
CAS No.	1848242-58-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8 mg/mL (16.71 mM), Sonication is recommended.

References and Literature

1. Yu T, et al. Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR. ACS Med Chem Lett. 2018 Feb 27;9(3):256-261.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Ovarian Cancer Compound Library Anti-Cancer Metabolism Compound Library Metabolism Compound Library Antidepressant Compound Library Bioactive Compounds Library Max Anti-Colorectal Cancer Compound Library Anti-Aging Compound Library Neuronal Differentiation Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PI3K/mTOR Inhibitor-2 1848242-58-9 PI3K/Akt/mTOR signaling PI3K mTOR inhibit Inhibitor PI-3K/mTOR Inhibitor-2 PI3K/mTOR Inhibitor2 PI3K/mTOR Inhibitor 2 Mammalian target of Rapamycin Phosphoinositide 3-kinase inhibitor

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