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PI4KIII beta inhibitor 3

Catalog No. T12467   CAS 1245319-54-3

PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).

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PI4KIII beta inhibitor 3 Chemical Structure
PI4KIII beta inhibitor 3, CAS 1245319-54-3
Pack Size Availability Price/USD Quantity
25 mg 6-8 weeks $ 1,080.00
50 mg 6-8 weeks $ 1,410.00
100 mg 6-8 weeks $ 2,140.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
Targets&IC50 PI4KIIIβ:5.7 nM
In vitro PI4KIII beta inhibitor 3 is a PI4KIII inhibitor, has an IC50 of 5.7 nM. PI4KIII beta inhibitor 3 exerts significant immunosuppressive activity, with IC50 value of 3 nM in the mixed lymphocyte reaction (MLR) assay. PI4KIII beta inhibitor 3 inhibits IL2 and IFNy secretion with IC50 values of less than InM in each case. Thus, PI4KIII beta inhibitor 3 is shown to be as effective at inhibiting IL2 and IFNy secretion as conventional immunosuppressants such as cyclosporine A. IC50 on IFNy and IL-2 release of Cyclosporine A are 2nM and less than 1 nM respectively[1].
In vivo Oral administration of PI4KIII beta inhibitor 3 results in prolonged graft survival in 3 out of 6 grafts in each group at day 30. Several grafts continued beating after withdrawal of the treatment (up to 60 days), indicating the induction of a certain type of graft tolerance. To evaluate the operational tolerance phenotype, animals with functional graft at day 60 are challenged with a second graft from the same donor strain or from a third party.
Molecular Weight 446.53
Formula C22H22N8OS
CAS No. 1245319-54-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (44.79 mM), sonification is recommended.

TargetMolReferences and Literature

1. Jean Herman, et al. Autoimmune and inflammatory disorder therapy. From PCT Int. Appl. (2013), WO 2013034738 A1

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Keywords

PI4KIII beta inhibitor 3 1245319-54-3 PI3K/Akt/mTOR signaling PI3K PI-4KIII beta inhibitor 3 PI4KIII β inhibitor 3 PI4KIII b inhibitor 3 inhibitor inhibit

 

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