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PP58

Catalog No. T13824   CAS 212391-58-7

PP58 is an inhibitor of PDGFR, FGFR and Src family.

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PP58 Chemical Structure
PP58, CAS 212391-58-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 39.00
5 mg In stock $ 93.00
10 mg In stock $ 147.00
25 mg In stock $ 257.00
50 mg In stock $ 396.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PP58 is an inhibitor of PDGFR, FGFR and Src family.
In vitro PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM[1].
In vivo PP58 exhibits some degree of selectivity in vivo[1].
Molecular Weight 456.32
Formula C22H19Cl2N5O2
CAS No. 212391-58-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.3mg/mL (123.3mM), sonification is recommended.

TargetMolReferences and Literature

1. Wissing J, et al. Chemical Proteomic Analysis Reveals Alternative Modes of Action for Pyrido[2,3-d]pyrimidine Kinase Inhibitors. Mol Cell Proteomics. 2004 Dec;3(12):1181-93. 2. Blencke S, et al. Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors. Chem Biol. 2004 May;11(5):691-701.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library NF-κB Signaling Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Anti-Prostate Cancer Compound Library Anti-Ovarian Cancer Compound Library Anti-Lung Cancer Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library

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Keywords

PP58 212391-58-7 Angiogenesis Apoptosis MAPK Tyrosine Kinase/Adaptors PDGFR Src FGFR TNF p38 MAPK PP-58 PP 58 inhibitor inhibit

 

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