Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PP58 is an inhibitor of PDGFR, FGFR and Src family.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 93.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 257.00 | |
50 mg | In stock | $ 396.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | PP58 is an inhibitor of PDGFR, FGFR and Src family. |
In vitro | PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50 < 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM[1]. |
In vivo | PP58 exhibits some degree of selectivity in vivo[1]. |
Molecular Weight | 456.32 |
Formula | C22H19Cl2N5O2 |
CAS No. | 212391-58-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.3mg/mL (123.3mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PP58 212391-58-7 Angiogenesis Apoptosis MAPK Tyrosine Kinase/Adaptors PDGFR Src FGFR TNF p38 MAPK PP-58 PP 58 inhibitor inhibit