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PR 39 (porcine) acetate

Catalog No. TP1961L

PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PR 39 (porcine) acetate Chemical Structure

PR 39 (porcine) acetate, CAS N/A

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 197.00
5 mg	Inquiry	$ 497.00
10 mg	Inquiry	$ 746.00
25 mg	Inquiry	$ 1,342.00
50 mg	Inquiry	$ 1,997.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor. PR 39 (porcine) acetate reversibly binds to the α7 subunit of the proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway.
In vitro	PR-39 (100 nM) blocks TNF-α-induced (1 ng/mL; for 20 minutes) activation of VCAM-1 (2 hours) and ICAM-1 (8 hours) expression in human umbilical vein endothelial cells (HUVEC)[2]. PR-39 (10 μM) does not affect the ability to proliferate of ECV304 cell. PR39 is able to inhibit IκBα degradation without significantly affecting overall protein degradation in cells[2].
In vivo	PR-39 stimulates angiogenesis, inhibits inflammatory responses and significant reduces myocardial infarct size in mice. PR-39 (10 mg/kg, intravenously; 1 hour before Caerulein of 50μg/kg, ip) blocks IκBα degradation and NF-κB-dependent transcription in the mouse pancreas after induction of acute pancreatitis. PR-39 (1 μg/kg/day; 7-day intraperitoneal infusion) demonstrates significantly small infarct in C57BL/6 mice[2].

Molecular Weight

N/A

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Maria Gaczynska, et al. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry. 2003 Jul 29;42(29):8663-70. 2. Y Gao, et al. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000 Aug;106(3):439-48.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PR 39 (porcine) acetate Microbiology/Virology Proteases/Proteasome Ubiquitination Antibacterial Proteasome PR 39 (porcine) Acetate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.