Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
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Description | PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1]. |
In vitro | Treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) notably enhanced the polyubiquitination of EGFP-FKBP within the first hour, indicating its efficacy in promoting VHL-related protein degradation. This process involves the recruitment of endogenous VHL by PROTAC FKBP Degrader-3 (compound 10), during which ubiquitination was observed specifically at one background lysine residue (Lys158) of EGFP[1]. |
Molecular Weight | 1295.54 |
Formula | C68H90N6O17S |
CAS No. | 2079056-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PROTAC FKBP Degrader-3 2079056-43-0 Others PROTAC FKBP Degrader 3 PROTAC FKBP Degrader3 inhibitor inhibit