Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively).
Description | PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM , respectively). |
Targets&IC50 | PDK3:2.1 μM , PDK1:21.3 μM , PDK2:0.8 μM , PDK4:0.76 μM |
In vivo | PS10, inhibits all four PDK isoforms with IC50 = 0.8 μM for PDK2.?The administration of PS10 (70 mg/kg) to diet-induced obese mice significantly augments pyruvate dehydrogenase complex activity with reduced phosphorylation in different tissues.?Prolonged PS10 treatments result in improved glucose tolerance and notably lessened hepatic steatosis in the mouse model. |
Molecular Weight | 323.32 |
Formula | C14H13NO6S |
CAS No. | 1564265-82-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PS10 1564265-82-2 PI3K/Akt/mTOR signaling PDK PS-10 PS 10 inhibitor inhibit