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PSN 375963

Catalog No. T23204 CAS 388575-52-8

Synonyms: PSN 375963 hydrochloride

PSN 375963 (PSN 375963 hydrochloride) hydrochloride is a synthetic agonist of the endogenous ligand for GPR119.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

PSN 375963, CAS 388575-52-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
2 mg	In stock	$ 40.00
5 mg	In stock	$ 64.00
10 mg	In stock	$ 98.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 328.00
100 mg	In stock	$ 538.00
200 mg	In stock	$ 767.00
500 mg	In stock	$ 1,150.00
1 mL * 10 mM (in DMSO)	In stock	$ 96.00

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Purity: 99.24%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PSN 375963 (PSN 375963 hydrochloride) hydrochloride is a synthetic agonist of the endogenous ligand for GPR119.
Targets&IC50	GPR119:7.9 μM(EC50,mouse), GPR119:8.4(EC50,human)
In vitro	PSN 375963 is a potent GPR119 agonist with EC50s of 8.4 and 7.9 μM for human and mouse GPR119[1].
In vivo	PSN 375963 suppressed food intake in rats and reduced body weight gain and white adipose tissue deposition upon subchronic oral administration to high-fat-fed rats[2].

Synonyms	PSN 375963 hydrochloride
Molecular Weight	285.38
Formula	C17H23N3O
CAS No.	388575-52-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4 mg/ml(12.43 mM)

Ethanol: 24 mg/ml(74.57 mM)

References and Literature

1. Ning Y, et al. Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells. Br J Pharmacol. 2008;155(7):1056-1065. 2. Overton HA, et al. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 2006;3(3):167-175.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Diabetic Compound Library Endocrinology-Hormone Compound Library Neuronal Signaling Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PSN 375963 388575-52-8 Endocrinology/Hormones GPCR/G Protein GPR Inhibitor inhibit PSN 375963 Hydrochloride receptor PSN-375963 G Protein-Coupled Receptor 119 endogenous PSN 375963 hydrochloride GPR119 PSN375963 Hydrochloride PSN-375963 Hydrochloride ligand PSN375963 orphan cAMP inhibitor

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