keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 40.00 | |
10 mg | In stock | $ 63.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 147.00 | |
100 mg | In stock | $ 217.00 | |
200 mg | In stock | $ 323.00 | |
500 mg | In stock | $ 546.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity. |
Targets&IC50 | HDAC6:82 nM , HDAC:27 nM (Hela cell) |
In vitro | PXD101 is a novel hydroxamate-type inhibitor of histone deacetylase activity that inhibits histone deacetylase activity in HeLa cell extracts with an IC(50) of 27 nM and induces a concentration-dependent (0.2-5 micro M) increase in acetylation of histone H4 in tumor cell lines.?PXD101 is cytotoxic in vitro in a number of tumor cell lines with IC(50)s in the range 0.2-3.4 micro M as determined by a clonogenic assay and induces apoptosis. |
In vivo | Treatment of nude mice bearing human ovarian and colon tumor xenografts with PXD101 (10-40 mg/kg/day i.p.) daily for 7 days causes a significant dose-dependent growth delay with no obvious signs of toxicity to the mice.?Growth delay is also observed for xenografts of cisplatin-resistant ovarian tumor cells.?A marked increase in acetylation of H4 is detected in blood and tumor of mice 3 h after treatment with PXD101.?The inhibition of growth of human tumor xenografts in mice, with no apparent toxicity, suggests that PXD101 has potential as a novel antitumor agent. |
Synonyms | PX105684, PXD101, PXD-101 |
Molecular Weight | 318.35 |
Formula | C15H14N2O4S |
CAS No. | 866323-14-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mg/mL (424.068 mM)
You can also refer to dose conversion for different animals. More
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Belinostat 866323-14-0 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases Inhibitor PX105684 PX-105684 PXD101 PXD 101 inhibit PX 105684 PXD-101 inhibitor