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Paederosidic acid

Catalog No. T5739 CAS 18842-98-3

Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GAD 65, may be a promising future therapeutic agent for treatment of epilepsy.

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Paederosidic acid, CAS 18842-98-3

Pack Size	Availability	Price/USD	Quantity
10 mg	In stock	$ 130.00
1 mL * 10 mM (in DMSO)	In stock	$ 100.00

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Purity: 99.96%

Purity: 98%

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Description	Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GAD 65, may be a promising future therapeutic agent for treatment of epilepsy.
In vitro	Paederosidic acid(PA) showed significant anti-tumor activity on lung cancer in vitro; the mechanisms were involved in inducing mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria.JNK phosphorylation levels significantly increased concomitantly with decrease in Akt phosphorylation after treatment with PA in A549 cells. However, JNK siRNA-transfected cells diminished PA-induced caspase-3, 8 and 9, Bid and Bax activaton while enhanced the Bcl-2 activation. PA-induced JNK activation played an important functional role in apoptosis[1].
In vivo	Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats.Paederosidic acid (5, 10, 20, and 40 mg/kg, ip) had significant anticonvulsant and sedative effects. paederosidic acid increased brain gamma-aminobutyric acid and decreased glutamic acid in the brain, and it up-regulated expressions of GAD 65. Paederosidic acid may be a promising future therapeutic agent for treatment of epilepsy[2].
Cell Research	The anti-proliferative effects of PA on A549 cells were evaluated by MTT method and the IC50 values were calculated. Furthermore, the PA-induced apoptosis in A549 cells was determined by fluorescence microscope via staining with DAPI and by flow cytometer via staining with FITC conjugated Annexin V/PI. The expression of apoptosis-related or signaling proteins was investigated by Western blotting[1]
Animal Research	Anticonvulsant activities of paederosidic acid were evaluated by maximal electroshock and pentylenetetrazole-induced seizures in male mice. Then, pentobarbital sodium-induced sleeping time and locomotor activity tests in mice were used to evaluate the sedative effects of paederosidic acid. Finally, the mechanism of paederosidic acid was explored by evaluating the contents of Glu and GABA in the brain, and Western blot was used to measure GAD65 expression in the mouse brain[2].
Source	Natural Products > Rubiaceae > Paederia

Molecular Weight	464.44
Formula	C18H24O12S
CAS No.	18842-98-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (118.42 mM)

References and Literature

1. Yu P , Shi L , Song M , et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis[J]. Chemico-Biological Interactions, 2017, 269:33-40. 2. Yang T , Kong B , Gu J W , et al. Anticonvulsant and Sedative Effects of Paederosidic Acid isolated from Paederia scandens (Lour.) Merrill. in Mice and Rats[J]. Pharmacology Biochemistry and Behavior, 2013, 111.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Cuproptosis Compound Library Covalent Natural Product Library Natural Product Library Anti-Lung Cancer Compound Library Terpene Natural Product Library Covalent Inhibitor Library Anti-Tumor Natural Product Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

Paederosidic acid 18842-98-3 Apoptosis BCL cancer A549 inhibit Lung acid Paederosidic Inhibitor inhibitor

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