Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 50.00 | |
100 mg | In stock | $ 88.00 | |
500 mg | In stock | $ 252.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Paliperidone (9-hydroxyrisperidone)(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone. |
In vitro | Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. [1] Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. [2] Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone. [3] |
Synonyms | 9-hydroxyrisperidone |
Molecular Weight | 426.48 |
Formula | C23H27FN4O3 |
CAS No. | 144598-75-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.3 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Paliperidone 144598-75-4 GPCR/G Protein Immunology/Inflammation Neuroscience Adrenergic Receptor Histamine Receptor 5-HT Receptor Dopamine Receptor schizophrenia antipsychotic atypical inhibit 5-hydroxytryptamine Receptor Beta Receptor metabolite Inhibitor Serotonin Receptor 9-hydroxyrisperidone inhibitor